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Institutional Holdings of VERTEX PHARMACEUTICALS INCORPORATED (VRTX) on 12/31/2011

1. Company Information

Company/StockVERTEX PHARMACEUTICALS INCORPORATED (stock symbol: VRTX)
Funds Ownership269 out of total 3028 funds (9%) own this stock
Funds own total 186,618,553 shares, 90.59% of all outstanding shares
Funds BOUGHT 2,313,636 more shares (+1.26%) in the quarter ended on 12/31/2011

2. Top 20 Funds Held VRTX in this Quarter (By Shares) Add to Yahoo Finance Message Board

No.FundSharesPut/CallActivity(Shr)% Port.% Out. Shrs
1.)FMR LLC19,383,839Cut -29.80%0.13%9.41%
2.)CAPITAL WORLD INVESTORS12,816,838Cut -31.36%0.16%6.22%
3.)JANUS CAPITAL MANAGEMENT LLC11,988,646New0.47%5.82%
4.)JENNISON ASSOCIATES LLC10,425,330Cut -99.28%0.49%5.06%
5.)VANGUARD GROUP INC8,629,868Added 2.22%0.05%4.19%
6.)D E SHAW & CO INC6,870,602Added 105.82%0.62%3.34%
7.)J P MORGAN CHASE & CO6,383,360Added 2,816.60%0.10%3.10%
8.)STATE STREET CORP5,871,242Added 2.99%0.03%2.85%
9.)WESTFIELD CAPITAL MANAGEMENT CO LLC5,549,745Added 31.68%1.36%2.69%
10.)BLACKROCK INSTITUTIONAL TRUST COMPANY NA5,412,810Added 10.35%0.05%2.63%
11.)BLACKROCK FUND ADVISORS5,393,274Added 0.24%0.10%2.62%
12.)CLEARBRIDGE ADVISORS LLC5,225,045Cut -1.54%0.35%2.54%
13.)GOLDMAN SACHS GROUP INC4,688,789Added 1,422.25%0.08%2.28%
14.)WELLINGTON MANAGEMENT CO LLP4,211,168Cut -22.48%0.06%2.04%
15.)WADDELL & REED FINANCIAL INC4,098,250Cut -15.14%0.34%1.99%
16.)LOOMIS SAYLES & CO L P4,021,300Cut -8.72%0.63%1.95%
17.)BLACKROCK GROUP LTD3,634,582Added 25.14%0.10%1.76%
18.)BROOKSIDE CAPITAL MANAGEMENT LLC3,417,178Cut -34.16%2.72%1.66%
19.)PRICE T ROWE ASSOCIATES INC MD 3,132,276Cut -27.18%0.04%1.52%
20.)BB BIOTECH AG2,997,684Added 10.02%11.20%1.46%



3. Top 20 Funds Held VRTX in this Quarter (By % of Portfolio) Add to Yahoo Finance Message Board

No.FundSharesPut/CallActivity(Shr)% Port.% Out. Shrs
1.)BB BIOTECH AG2,997,684Added 10.02%11.20%1.46%
2.)PERCEPTIVE ADVISORS LLC626,700Added 108.90%4.76%0.30%
3.)NOBLE PARTNERS L P15,000New3.51%0.01%
4.)BROOKSIDE CAPITAL MANAGEMENT LLC3,417,178Cut -34.16%2.72%1.66%
5.)HAMBRECHT & QUIST CAPITAL MANAGEMENT LLC331,253Cut -34.38%2.31%0.16%
6.)TRILOGY GLOBAL ADVISORS LLC1,637,477New1.40%0.79%
7.)WESTFIELD CAPITAL MANAGEMENT CO LLC5,549,745Added 31.68%1.36%2.69%
8.)TOBAM228,700New1.32%0.11%
9.)HEALTHCOR MANAGEMENT LP1,000,000New1.25%0.49%
10.)HUSSMAN ECONOMETRICS ADVISORS INC1,800,000New0.96%0.87%
11.)GERRY FARBER LLC24,000New0.77%0.01%
12.)LOOMIS SAYLES & CO L P4,021,300Cut -8.72%0.63%1.95%
13.)D E SHAW & CO INC6,870,602Added 105.82%0.62%3.34%
14.)FAN ASSET MANAGEMENT LLC27,420Added 15.99%0.61%0.01%
15.)VINIK ASSET MANAGEMENT L P826,300New0.55%0.40%
16.)TRAXIS PARTNERS LP67,810New0.51%0.03%
17.)JENNISON ASSOCIATES LLC10,425,330Cut -99.28%0.49%5.06%
18.)JANUS CAPITAL MANAGEMENT LLC11,988,646New0.47%5.82%
19.)TEALWOOD ASSET MANAGEMENT INC26,585Cut -22.14%0.46%0.01%
20.)ZEVENBERGEN CAPITAL INVESTMENTS LLC309,600Cut -0.06%0.43%0.15%

4. Top 20 Funds BOUGHT NEW VRTX in this Quarter (By Shares) Add to Yahoo Finance Message Board

No.FundSharesPut/Call% Port.% Out. Shrs
1.)JANUS CAPITAL MANAGEMENT LLC11,988,6460.47%5.82%
2.)CREDIT SUISSE 1,906,500CALL0.08%0.93%
3.)HUSSMAN ECONOMETRICS ADVISORS INC1,800,0000.96%0.87%
4.)OPPENHEIMER FUNDS INC1,761,1800.11%0.85%
5.)TRILOGY GLOBAL ADVISORS LLC1,637,4771.40%0.79%
6.)NWQ INVESTMENT MANAGEMENT CO LLC1,223,7400.26%0.59%
7.)HEALTHCOR MANAGEMENT LP1,000,0001.25%0.49%
8.)VINIK ASSET MANAGEMENT L P826,3000.55%0.40%
9.)TOBAM228,7001.32%0.11%
10.)WESTPAC BANKING CORP219,2910.14%0.11%
11.)CREDIT SUISSE 184,700PUT0.01%0.09%
12.)WEISS GEORGE A171,8000.19%0.08%
13.)ZURCHER KANTONALBANK (ZURICH CANTONALBANK)128,8580.20%0.06%
14.)VAN ECK ASSOCIATES CORP87,7630.01%0.04%
15.)VIRGINIA RETIREMENT SYSTEMS ET AL81,5070.05%0.04%
16.)ABSOLUTE RETURN CAPITAL LLC78,5210.40%0.04%
17.)FJARDE AP FONDEN (THE FOURTH SWEDISH NATIONAL PENSIONFUND)78,4230.06%0.04%
18.)SCOPIA MANAGEMENT INC72,3120.13%0.04%
19.)TRAXIS PARTNERS LP67,8100.51%0.03%
20.)COWEN GROUP INC65,400CALL0.17%0.03%

5. Top 20 Funds SOLD OUT VRTX in this Quarter (By Shares) Add to Yahoo Finance Message Board

No.FundSharesPut/Call% Port.% Out. Shrs
1.)JANUS CAPITAL MANAGEMENT LLC13,318,7200.73%6.47%
2.)CALAMOS ADVISORS LLC2,284,8250.50%1.11%
3.)SECTORAL ASSET MANAGEMENT INC890,9881.75%0.43%
4.)AMERICAN CENTURY COMPANIES INC715,4000.06%0.35%
5.)CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM428,5400.05%0.21%
6.)LOS ANGELES CAPITAL MANAGEMENT & EQUITY RESEARCH INC248,6920.32%0.12%
7.)AXA FINANCIAL INC235,6860.07%0.11%
8.)ORBIMED ADVISORS LLC230,000PUT0.38%0.11%
9.)GW CAPITAL MANAGEMENT LLC213,2020.32%0.10%
10.)GREEN ARROW CAPITAL MANAGEMENT LLC200,000CALL2.14%0.10%
11.)HERMES FUND MANAGERS (NORTH AMERICA) LP163,7261.65%0.08%
12.)DEERFIELD MANAGEMENT CO NY150,000PUT0.38%0.07%
13.)TIMBER HILL LLC136,100CALL0.02%0.07%
14.)TIMBER HILL LLC104,000PUT0.01%0.05%
15.)HARVEY CAPITAL MANAGEMENT INC93,7003.33%0.05%
16.)CALDWELL & ORKIN INC93,0002.89%0.05%
17.)GREAT WEST LIFE ASSURANCE CO CAN 70,4000.03%0.03%
18.)NLI INTERNATIONAL INC66,2430.54%0.03%
19.)DRIEHAUS CAPITAL MANAGEMENT LLC56,1450.14%0.03%
20.)COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS51,2260.05%0.02%