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Institutional Holdings of THE MEDICINES COMPANY (MDCO) on 12/31/2011

1. Company Information

Company/StockTHE MEDICINES COMPANY (stock symbol: MDCO)
Funds Ownership148 out of total 3028 funds (5%) own this stock
Funds own total 52,051,765 shares, 97.80% of all outstanding shares
Funds SOLD -536,380 shares (-1.02%) in the quarter ended on 12/31/2011

2. Top 20 Funds Held MDCO in this Quarter (By Shares) Add to Yahoo Finance Message Board

No.FundSharesPut/CallActivity(Shr)% Port.% Out. Shrs
1.)PRICE T ROWE ASSOCIATES INC MD 5,641,375Cut -1.30%0.04%10.60%
2.)WELLINGTON MANAGEMENT CO LLP4,755,247Cut -16.51%0.04%8.94%
3.)D E SHAW & CO INC4,663,090Cut -3.97%0.24%8.76%
4.)VANGUARD GROUP INC3,517,951Added 3.08%0.01%6.61%
5.)BLACKROCK FUND ADVISORS2,703,383Added 5.16%0.03%5.08%
6.)DEERFIELD MANAGEMENT CO NY2,054,897Cut -50.06%2.01%3.86%
7.)BLACKROCK INSTITUTIONAL TRUST COMPANY NA1,568,512Added 3.00%0.01%2.95%
8.)ROYCE & ASSOCIATES LLC1,436,150Cut -0.01%0.09%2.70%
9.)STATE STREET CORP1,407,232Cut -1.84%0.01%2.64%
10.)SOROS FUND MANAGEMENT LLC1,250,000Cut -26.47%0.51%2.35%
11.)LORD ABBETT & CO LLC1,060,913New0.05%1.99%
12.)DIMENSIONAL FUND ADVISORS INC991,876Added 5.19%0.02%1.86%
13.)RENAISSANCE TECHNOLOGIES LLC984,732Added 76.21%0.08%1.85%
14.)SAC CAPITAL ADVISORS LP780,797Added 2,635.42%0.09%1.47%
15.)NORTHERN TRUST CORP759,236Cut -0.57%0.01%1.43%
16.)RIDGEBACK CAPITAL INVESTMENTS LP748,499Cut -45.79%9.32%1.41%
17.)OPPENHEIMER FUNDS INC735,898Added 0.92%0.03%1.38%
18.)CADENCE CAPITAL MANAGEMENT LLC658,940New0.32%1.24%
19.)J GOLDMAN & CO LP650,000Cut -99.87%3.87%1.22%
20.)ING INVESTMENT MANAGEMENT CO564,146Cut -12.51%0.04%1.06%



3. Top 20 Funds Held MDCO in this Quarter (By % of Portfolio) Add to Yahoo Finance Message Board

No.FundSharesPut/CallActivity(Shr)% Port.% Out. Shrs
1.)RIDGEBACK CAPITAL INVESTMENTS LP748,499Cut -45.79%9.32%1.41%
2.)J GOLDMAN & CO LP650,000Cut -99.87%3.87%1.22%
3.)PRIVATE CAPITAL ADVISORS INC372,950Cut -31.68%2.79%0.70%
4.)REDMILE GROUP LLC331,900New2.31%0.62%
5.)DEERFIELD MANAGEMENT CO NY2,054,897Cut -50.06%2.01%3.86%
6.)TRELLUS MANAGEMENT COMPANY LLC100,000Cut -8.59%1.43%0.19%
7.)ABINGWORTH LLP107,000Unchanged1.24%0.20%
8.)FOXHALL CAPITAL MANAGEMENT INC16,310New0.78%0.03%
9.)SPARK LP DE160,400Cut -14.59%0.75%0.30%
10.)PERELLA WEINBERG PARTNERS CAPITAL MANAGEMENT LP389,555Added 1.99%0.75%0.73%
11.)HIGHLINE CAPITAL MANAGEMENT LLC547,000Cut -17.74%0.74%1.03%
12.)HILLSDALE INVESTMENT MANAGEMENT INC85,500Unchanged0.60%0.16%
13.)SOROS FUND MANAGEMENT LLC1,250,000Cut -26.47%0.51%2.35%
14.)ORIGIN ASSET MANAGEMENT LLP445,632New0.48%0.84%
15.)POINTSTATE CAPITAL LP300,000New0.43%0.56%
16.)TSP CAPITAL MANAGEMENT GROUP LLC35,000Unchanged0.42%0.07%
17.)CADENCE CAPITAL MANAGEMENT LLC658,940New0.32%1.24%
18.)CLARIVEST ASSET MANAGEMENT LLC268,442New0.29%0.50%
19.)D E SHAW & CO INC4,663,090Cut -3.97%0.24%8.76%
20.)GOTHAM ASSET MANAGEMENT LLC82,351Added 12.01%0.19%0.15%

4. Top 20 Funds BOUGHT NEW MDCO in this Quarter (By Shares) Add to Yahoo Finance Message Board

No.FundSharesPut/Call% Port.% Out. Shrs
1.)LORD ABBETT & CO LLC1,060,9130.05%1.99%
2.)CADENCE CAPITAL MANAGEMENT LLC658,9400.32%1.24%
3.)ORIGIN ASSET MANAGEMENT LLP445,6320.48%0.84%
4.)SOROS FUND MANAGEMENT LLC350,000CALL0.14%0.66%
5.)REDMILE GROUP LLC331,9002.31%0.62%
6.)POINTSTATE CAPITAL LP300,0000.43%0.56%
7.)CLARIVEST ASSET MANAGEMENT LLC268,4420.29%0.50%
8.)OXFORD ASSET MANAGEMENT104,7230.05%0.20%
9.)MILLENNIUM MANAGEMENT LLC84,1540.01%0.16%
10.)TWO SIGMA INVESTMENTS LLC65,2390.01%0.12%
11.)MADISON SQUARE INVESTORS LLC61,0760.01%0.11%
12.)GUGGENHEIM CAPITAL LLC54,8230.01%0.10%
13.)ANALYTIC INVESTORS INC CA45,0620.02%0.08%
14.)PARALLAX VOLATILITY ADVISERS LLC42,1000.01%0.08%
15.)NUMERIC INVESTORS LLC31,3000.01%0.06%
16.)FIRST TRUST ADVISORS LP24,5190.01%0.05%
17.)JEFFERIES GROUP INC DE 23,8400.00%0.04%
18.)MANAGED ACCOUNT ADVISORS LLC17,2000.00%0.03%
19.)KNIGHT CAPITAL GROUP INC16,5620.01%0.03%
20.)FOXHALL CAPITAL MANAGEMENT INC16,3100.78%0.03%

5. Top 20 Funds SOLD OUT MDCO in this Quarter (By Shares) Add to Yahoo Finance Message Board

No.FundSharesPut/Call% Port.% Out. Shrs
1.)LSV ASSET MANAGEMENT803,1000.04%1.51%
2.)BRANDYWINE ASSET MANAGEMENT LLC193,1620.04%0.36%
3.)GOLDEN CAPITAL MANAGEMENT LLC121,4960.11%0.23%
4.)KENNEDY CAPITAL MANAGEMENT INC84,8100.04%0.16%
5.)GW CAPITAL MANAGEMENT LLC72,9250.04%0.14%
6.)MADISON SQUARE INVESTORS LLC66,6500.01%0.13%
7.)VIRGINIA RETIREMENT SYSTEMS ET AL41,8000.01%0.08%
8.)MARINER QUANTITATIVE SOLUTIONS LLC41,7500.52%0.08%
9.)UNIONBANCAL CORP31,5000.02%0.06%
10.)CAXTON ASSOCIATES LLC28,1390.02%0.05%
11.)BNP PARIBAS ARBITRAGE SA19,0910.00%0.04%
12.)BNP PARIBAS ARBITRAGE SNC19,0910.00%0.04%
13.)SUSQUEHANNA INTERNATIONAL GROUP LLP18,0360.00%0.03%
14.)SANTA FE PARTNERS LLC17,4930.04%0.03%
15.)AXA FINANCIAL INC10,7300.00%0.02%
16.)BASCOM HILL PARTNERS LLC10,0000.09%0.02%
17.)CENTRAL TRUST & INVESTMENT CO2,4000.00%0.00%
18.)J GOLDMAN & CO LP1,200CALL0.07%0.00%