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Institutional Holdings of CARDIOME PHARMA CORPORATION (CRME) on 12/31/2011

1. Company Information

Company/StockCARDIOME PHARMA CORPORATION (stock symbol: CRME)
Funds Ownership59 out of total 3028 funds (2%) own this stock
Funds own total 38,299,843 shares, 62.65% of all outstanding shares
Funds SOLD -2,966,654 shares (-7.19%) in the quarter ended on 12/31/2011

2. Top 20 Funds Held CRME in this Quarter (By Shares) Add to Yahoo Finance Message Board

No.FundSharesPut/CallActivity(Shr)% Port.% Out. Shrs
1.)FMR LLC8,974,063Cut -0.25%0.01%14.68%
2.)ADAGE CAPITAL PARTNERS GP LLC6,661,300Unchanged0.08%10.90%
3.)BRIDGER MANAGEMENT LLC3,389,830Added 16.05%0.57%5.55%
4.)PRICE T ROWE ASSOCIATES INC MD 2,184,821Added 3.69%0.00%3.57%
5.)PIONEER INVESTMENT MANAGEMENT INC2,173,064Added 9.82%0.02%3.55%
6.)BANK OF NEW YORK MELLON CORP1,629,120Cut -0.53%0.00%2.67%
7.)AGF FUNDS INC1,610,817Cut -4.68%0.08%2.64%
8.)TIGER MANAGEMENT LLC NY1,596,106Cut -18.26%1.76%2.61%
9.)KOPP INVESTMENT ADVISORS LLC1,272,952Cut -21.20%1.41%2.08%
10.)SUTTONBROOK CAPITAL MANAGEMENT LP1,038,555Unchanged0.81%1.70%
11.)WELLINGTON MANAGEMENT CO LLP903,155Cut -45.31%0.00%1.48%
12.)PERIMETER CAPITAL PARTNERS LLC886,440Cut -30.26%0.15%1.45%
13.)FRANKLIN RESOURCES INC800,228Cut -3.03%0.00%1.31%
14.)IG INVESTMENT MANAGEMENT LTD568,484Cut -1.66%0.01%0.93%
15.)STRAUS CAPITAL MANAGEMENT LLC 492,932Unchanged0.62%0.81%
16.)ABINGWORTH LLP480,856Unchanged0.78%0.79%
17.)CANADA PENSION PLAN INVESTMENT BOARD420,437Unchanged0.01%0.69%
18.)BLACKROCK FUND ADVISORS410,596Added 1.91%0.00%0.67%
19.)GREAT WEST LIFE ASSURANCE CO CAN 277,520Cut -4.11%0.01%0.45%
20.)BLACKROCK INSTITUTIONAL TRUST COMPANY NA217,322Cut -11.47%0.00%0.36%



3. Top 20 Funds Held CRME in this Quarter (By % of Portfolio) Add to Yahoo Finance Message Board

No.FundSharesPut/CallActivity(Shr)% Port.% Out. Shrs
1.)TIGER MANAGEMENT LLC NY1,596,106Cut -18.26%1.76%2.61%
2.)KOPP INVESTMENT ADVISORS LLC1,272,952Cut -21.20%1.41%2.08%
3.)SUTTONBROOK CAPITAL MANAGEMENT LP1,038,555Unchanged0.81%1.70%
4.)ABINGWORTH LLP480,856Unchanged0.78%0.79%
5.)STRAUS CAPITAL MANAGEMENT LLC 492,932Unchanged0.62%0.81%
6.)BRIDGER MANAGEMENT LLC3,389,830Added 16.05%0.57%5.55%
7.)NOBLE PARTNERS L P26,100Cut -72.84%0.49%0.04%
8.)ROTELLA CAPITAL MANAGEMENT INC18,625New0.25%0.03%
9.)PERIMETER CAPITAL PARTNERS LLC886,440Cut -30.26%0.15%1.45%
10.)PERKINS CAPITAL MANAGEMENT INC70,000Unchanged0.12%0.11%
11.)BERSON & CORRADO INVESTMENT ADVISORS LLC61,500Added 51.85%0.12%0.10%
12.)AGF FUNDS INC1,610,817Cut -4.68%0.08%2.64%
13.)ADAGE CAPITAL PARTNERS GP LLC6,661,300Unchanged0.08%10.90%
14.)WOODSTOCK CORP107,511Unchanged0.07%0.18%
15.)1798 GLOBAL PARTNERS (CAYMAN ISLANDS) LTD145,765New0.04%0.24%
16.)TECHNICAL FINANCIAL SERVICES LLC178,171Cut -7.85%0.03%0.29%
17.)PIONEER INVESTMENT MANAGEMENT INC2,173,064Added 9.82%0.02%3.55%
18.)WEISS MULTI STRATEGY ADVISERS LLC200,000Added 11.11%0.02%0.33%
19.)WEISS GEORGE A200,000New0.02%0.33%
20.)SVENSON SCOTT20,000New0.01%0.03%

4. Top 20 Funds BOUGHT NEW CRME in this Quarter (By Shares) Add to Yahoo Finance Message Board

No.FundSharesPut/Call% Port.% Out. Shrs
1.)WEISS GEORGE A200,0000.02%0.33%
2.)1798 GLOBAL PARTNERS (CAYMAN ISLANDS) LTD145,7650.04%0.24%
3.)RENAISSANCE TECHNOLOGIES LLC55,0680.00%0.09%
4.)CITADEL ADVISORS LLC31,8250.00%0.05%
5.)MILLENNIUM MANAGEMENT LLC20,7250.00%0.03%
6.)SVENSON SCOTT20,0000.01%0.03%
7.)ROTELLA CAPITAL MANAGEMENT INC18,6250.25%0.03%
8.)D E SHAW & CO INC11,0640.00%0.02%
9.)JANNEY MONTGOMERY SCOTT LLC10,0000.00%0.02%
10.)PENN MUTUAL LIFE INSURANCE CO10,0000.00%0.02%
11.)FIRST ALLIED SECURITIES INC5000.00%0.00%

5. Top 20 Funds SOLD OUT CRME in this Quarter (By Shares) Add to Yahoo Finance Message Board

No.FundSharesPut/Call% Port.% Out. Shrs
1.)ANDREEFF EQUITY ADVISORS LLC699,7890.91%1.14%
2.)AMERIPRISE FINANCIAL INC91,4530.00%0.15%
3.)MORGAN STANLEY66,6620.00%0.11%
4.)OPPENHEIMER & CO INC40,0000.01%0.07%
5.)RIMA MANAGEMENT LLC20,0000.02%0.03%
6.)BLACKROCK GROUP LTD17,0350.00%0.03%
7.)MENTA CAPITAL LLC16,9000.05%0.03%
8.)BARCLAYS PLC16,900PUT0.00%0.03%
9.)SOROS FUND MANAGEMENT LLC13,8000.00%0.02%
10.)NORTH STAR INVESTMENT MANAGEMENT CORP6,3000.01%0.01%
11.)CREDIT AGRICOLE S A4,1000.00%0.01%
12.)ACADIAN ASSET MANAGEMENT LLC1100.00%0.00%