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Institutional Holdings of AMYLIN PHARMACEUTICALS, INC. (AMLN) on 12/31/2011

1. Company Information

Company/StockAMYLIN PHARMACEUTICALS, INC. (stock symbol: AMLN)
Funds Ownership157 out of total 3028 funds (5%) own this stock
Funds own total 125,116,913 shares, 84.94% of all outstanding shares
Funds BOUGHT 5,396,112 more shares (+4.51%) in the quarter ended on 12/31/2011

2. Top 20 Funds Held AMLN in this Quarter (By Shares) Add to Yahoo Finance Message Board

No.FundSharesPut/CallActivity(Shr)% Port.% Out. Shrs
1.)FMR LLC21,924,640Added 0.25%0.05%14.88%
2.)WELLINGTON MANAGEMENT CO LLP19,937,550Added 3.03%0.09%13.54%
3.)ICAHN CARL C14,381,925Unchanged1.41%9.76%
4.)OPPENHEIMER FUNDS INC6,676,290Cut -0.11%0.14%4.53%
5.)VANGUARD GROUP INC6,522,442Added 1.29%0.01%4.43%
6.)KORNITZER CAPITAL MANAGEMENT INC KS5,953,673Cut -3.47%1.26%4.04%
7.)UBS GLOBAL ASSET MANAGEMENT AMERICAS INC5,527,242Added 12.92%0.10%3.75%
8.)PRICE T ROWE ASSOCIATES INC MD 3,772,600Added 292.53%0.02%2.56%
9.)BLACKROCK INSTITUTIONAL TRUST COMPANY NA3,070,001Added 10.60%0.01%2.08%
10.)STATE STREET CORP3,008,233Added 4.06%0.01%2.04%
11.)MILLENNIUM MANAGEMENT LLC2,812,059Added 36.74%0.27%1.91%
12.)BARCLAYS PLC2,574,500PUTAdded 469.45%0.04%1.75%
13.)SUSQUEHANNA INTERNATIONAL GROUP LLP2,412,800CALLAdded 185.78%0.01%1.64%
14.)BB BIOTECH AG2,388,139Unchanged3.06%1.62%
15.)SAC CAPITAL ADVISORS LP2,133,768Cut -30.70%0.15%1.45%
16.)PARTNER FUND MANAGEMENT LP1,825,820Cut -39.89%1.37%1.24%
17.)BLACKROCK FUND ADVISORS1,327,776Added 4.73%0.01%0.90%
18.)RENAISSANCE TECHNOLOGIES LLC1,291,000Added 2,756.19%0.06%0.88%
19.)DEUTSCHE BANK AG 1,278,723Added 257.92%0.02%0.87%
20.)KINGDON CAPITAL MANAGEMENT LLC1,178,184New0.72%0.80%



3. Top 20 Funds Held AMLN in this Quarter (By % of Portfolio) Add to Yahoo Finance Message Board

No.FundSharesPut/CallActivity(Shr)% Port.% Out. Shrs
1.)BB BIOTECH AG2,388,139Unchanged3.06%1.62%
2.)REDMILE GROUP LLC625,000New2.65%0.42%
3.)SECTOR GAMMA ASA721,000Added 115.22%2.33%0.49%
4.)PARTNER INVESTMENT MANAGEMENT LP1,081,598Cut -33.63%2.20%0.73%
5.)ICAHN CARL C14,381,925Unchanged1.41%9.76%
6.)PARTNER FUND MANAGEMENT LP1,825,820Cut -39.89%1.37%1.24%
7.)KORNITZER CAPITAL MANAGEMENT INC KS5,953,673Cut -3.47%1.26%4.04%
8.)WETHERBY ASSET MANAGEMENT INC147,266Unchanged0.89%0.10%
9.)KINGDON CAPITAL MANAGEMENT LLC1,178,184New0.72%0.80%
10.)PLATTE RIVER CAPITAL LLC516,078Added 3.98%0.57%0.35%
11.)BOGLE INVESTMENT MANAGEMENT L P DE 171,183New0.48%0.12%
12.)DEERFIELD MANAGEMENT CO NY556,567New0.33%0.38%
13.)SMITH ASSET MANAGEMENT GROUP LP548,695New0.32%0.37%
14.)DEERFIELD MANAGEMENT CO NY500,000CALLNew0.30%0.34%
15.)PARTNER FUND MANAGEMENT LP3,925CALLNew0.30%0.00%
16.)MILLENNIUM MANAGEMENT LLC2,812,059Added 36.74%0.27%1.91%
17.)SPRINGBOK CAPITAL MANAGEMENT LLC56,259Cut -25.77%0.26%0.04%
18.)TRADEWORX INC11,587New0.25%0.01%
19.)CAXTON ASSOCIATES LLC585,194Added 38.54%0.21%0.40%
20.)GLOBEFLEX CAPITAL L P88,052Added 42.08%0.18%0.06%

4. Top 20 Funds BOUGHT NEW AMLN in this Quarter (By Shares) Add to Yahoo Finance Message Board

No.FundSharesPut/Call% Port.% Out. Shrs
1.)KINGDON CAPITAL MANAGEMENT LLC1,178,1840.72%0.80%
2.)CAPITAL WORLD INVESTORS850,0000.00%0.58%
3.)JANUS CAPITAL MANAGEMENT LLC845,9600.01%0.57%
4.)JACOBS LEVY EQUITY MANAGEMENT INC648,8870.11%0.44%
5.)REDMILE GROUP LLC625,0002.65%0.42%
6.)DEERFIELD MANAGEMENT CO NY556,5670.33%0.38%
7.)SMITH ASSET MANAGEMENT GROUP LP548,6950.32%0.37%
8.)DENVER INVESTMENT ADVISORS LLC523,9090.15%0.36%
9.)DEERFIELD MANAGEMENT CO NY500,000CALL0.30%0.34%
10.)JEFFERIES GROUP INC DE 405,300CALL0.04%0.28%
11.)KINGDON CAPITAL MANAGEMENT LLC250,000CALL0.15%0.17%
12.)MADISON SQUARE INVESTORS LLC217,8380.03%0.15%
13.)BOGLE INVESTMENT MANAGEMENT L P DE 171,1830.48%0.12%
14.)VAN ECK ASSOCIATES CORP88,2100.01%0.06%
15.)ZURCHER KANTONALBANK (ZURICH CANTONALBANK)80,0000.04%0.05%
16.)UBS OCONNOR LLC65,600PUT0.01%0.04%
17.)PRINCIPAL FINANCIAL GROUP INC62,7000.00%0.04%
18.)ROYAL BANK OF CANADA 59,700CALL0.00%0.04%
19.)JANE STREET HOLDING LLC52,4890.01%0.04%
20.)NOMURA HOLDINGS INC50,4000.00%0.03%

5. Top 20 Funds SOLD OUT AMLN in this Quarter (By Shares) Add to Yahoo Finance Message Board

No.FundSharesPut/Call% Port.% Out. Shrs
1.)FIRST TRUST ADVISORS LP1,886,3710.20%1.28%
2.)WESTFIELD CAPITAL MANAGEMENT CO LLC1,848,3400.14%1.25%
3.)JANUS CAPITAL MANAGEMENT LLC693,4050.01%0.47%
4.)TIAA CREF INVESTMENT MANAGEMENT LLC639,2090.01%0.43%
5.)HIGHBRIDGE CAPITAL MANAGEMENT LLC383,2940.04%0.26%
6.)AXA FINANCIAL INC177,1020.01%0.12%
7.)WALTER CAPITAL MANAGEMENT LLP175,000PUT0.55%0.12%
8.)WALTER CAPITAL MANAGEMENT LLP170,0000.53%0.12%
9.)WEINTRAUB CAPITAL MANAGEMENT LP150,0000.14%0.10%
10.)CANADA PENSION PLAN INVESTMENT BOARD118,6850.01%0.08%
11.)OPPENHEIMER & CO INC91,5400.05%0.06%
12.)TEACHERS ADVISORS INC48,8950.00%0.03%
13.)JENNISON ASSOCIATES LLC36,0480.00%0.02%
14.)HUNTER ASSOCIATES INC34,6500.14%0.02%
15.)MINTZ HAL34,600PUT0.73%0.02%
16.)BATTERYMARCH FINANCIAL MANAGEMENT INC31,0100.00%0.02%
17.)MADISON SQUARE INVESTORS LLC22,5390.00%0.02%
18.)SYNOVUS FINANCIAL CORP14,5000.01%0.01%
19.)SYMPHONY ASSET MANAGEMENT LLC12,7650.01%0.01%
20.)APERIO GROUP LLC11,7620.01%0.01%