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Fund Holdings of BAKER BROS ADVISORS LLC Filed on 2012-02-14

Link to Original SEC 13F filings sorted on filing date: 2012-02-14 | 2011-11-14 | 2011-08-15 | 2011-05-16 | 2011-02-14 | 2010-11-15 | 2010-08-16 | 2010-05-17 | 2010-02-16 | 2009-11-10 | 2009-05-15 | 2009-02-17 | 2008-11-14 | 2008-08-14 | 2008-05-15 |

1. Fund Information

Fund NameBAKER BROS ADVISORS LLC
Fund Manager
Address667 MADISON AVE, 21ST FLOOR
NEW YORK, NY, 10065
::Google Map
Phone(212) 339-5600
13F Asset Last Qtr$2,348,486,000
13F Asset This Qtr$3,025,796,000
Asset Change28.84%

2. Comparison of Holdings by Sectors with Last Quarter

3. Top 20 Holdings (Value) of This Quarter

No.SecurityPut/CallStockSharesValue(x$1000)Activity(Shr)% Port.
1.)SEATTLE GENETICS, INC.SGEN20,597,463$344,286Added 900.00%11.38%
2.)VIROPHARMA INCORPORATEDVPHM12,048,664$330,013Added 998.90%10.91%
3.)10/1/2015 CONV BONDS160,000,000$300,500Added 900.00%9.93%
4.)INCYTE CORPORATIONINCY15,549,112$233,392Added 1,303.28%7.71%
5.)56 SALIX 5.5% 8/15/28 CONV BONDS44,500,000$231,650Unchanged7.66%
6.)GENOMIC HEALTH, INC.GHDX8,781,344$222,959Added 11.67%7.37%
7.)PHARMASSET, INC.VRUS1,569,727$201,239Cut -61.65%6.65%
8.)SYNAGEVA BIOPHARMA CORPORATIONGEVA6,183,574$164,668New5.44%
9.)57 SALIX 2.75% 5/15/15 CONV BONDS100,572,000$129,361Added 888.51%4.28%
10.)AUXILIUM PHARMACEUTICALS, INC.AUXL6,461,354$128,775Unchanged4.26%
11.)PHARMACYCLICS, INC.PCYC8,013,514$118,760Added 13.97%3.92%
12.)GILEAD SCIENCES, INC.GILD2,886,861$118,159New3.91%
13.)ARDEA BIOSCIENCES, INC.RDEA6,011,989$101,061Unchanged3.34%
14.)ARIAD PHARMACEUTICALS, INC.ARIA5,403,560$66,194Added 323.16%2.19%
15.)MICROMET, INC.MITI3,978,438$28,605Added 12.26%0.95%
16.)INHIBITEX, INC.INHX2,274,095$24,879New0.82%
17.)52 GILEAD 1.625% 5/1/16 CONV BONDS21,500,000$24,503New0.81%
18.)MEDIVATION, INC.MDVN483,300$22,285Unchanged0.74%
19.)55 INTERMUNE INC NOTES 5% 3/1/15 CONV BONDS18,801,000$18,977Unchanged0.63%
20.)HALOZYME THERAPEUTICS, INC.HALO1,789,595$17,019Cut -38.98%0.56%

4. Top 20 (Value) Holdings BOUGHT NEW in This Quarter

No.SecurityPut/CallStockShares NEWValue(x$1000)% Port.
1.)SYNAGEVA BIOPHARMA CORPORATIONGEVA6,183,574$164,6685.44%
2.)GILEAD SCIENCES, INC.GILD2,886,861$118,1593.91%
3.)INHIBITEX, INC.INHX2,274,095$24,8790.82%
4.)52 GILEAD 1.625% 5/1/16 CONV BONDS21,500,000$24,5030.81%
5.)SPECTRUM PHARMACEUTICALS, INC.SPPI909,884$13,3120.44%
6.)CLOVIS ONCOLOGY INCCLVS350,000$4,9320.16%
7.)XENOPORT, INC.XNPT809,112$3,0830.10%
8.)TARGACEPT, INC.TRGT358,416$1,9960.07%
9.)LIGAND PHARMACEUTICALS INCORPORATEDLGND73,401$8710.03%
10.)VENTRUS BIOSCIENCES INCVTUS24,300$1950.01%
11.)ADVENTRX PHARMACEUTICALS INCANX64,692$380.00%

5. Top 20 (Value) Holdings Totally SOLD OUT in This Quarter

No.SecurityPut/CallStockShares SOLDValue(x$1000)% Port. Last Qtr
1.)ADOLOR CORPORATIONADLR6,947,343$11,9490.51%
2.)TRIMERIS, INC.TRMS3,475,475$8,7580.37%
3.)ZIOPHARM ONCOLOGY INCZIOP849,500$3,7460.16%
4.)IDENIX PHARMACEUTICALS, INC.IDIX572,576$2,8570.12%
5.)27 LIGAND PHARMACEUTICALS INC. CLASS B73,401$1,0040.04%
6.)VIA PHARMACEUTICALS INCVIAP102,881$20.00%